Table 3.

Sphingomyelin major species in healthy corneas and diabetics (n>=3 per group).

Major SM species were identified and quantified in human cadaver corneas from Healthy, T1DM, and T2DM donors. In healthy donors, C16:0 species were the highest followed by C24:1, C18:0, and C24:0. In T1DM, C16:0 species were also the highest followed by C18:0, C24:1, and C24:0. In T2DM, C16:0 was highest, C18:0 was second highest, followed by C24:1, and C24:0. At least three different samples from three different donors were used (n>=3).

Sphingomyelin Species	Healthy (pmol/mg tissue)	T1DM (pmol/mg tissue)	T2DM (pmol/mg tissue)
C14:0	8.93±2.31	2.28±0.37	1.48±0.23
C16:0	68.92±7.93	46.73±6.00	48.47±8.62
C18:1	6.20±1.49	2.38±0.38	1.85±0.29
C18:0	28.30±5.81	14.90±2.13	19.38±2.74
C20:0	9.76±1.89	4.57±0.41	5.42±0.70
C22:0	19.45±3.50	6.71±0.72	7.28±0.97
C24:1	36.96±7.85	10.12±1.17	11.07±1.56
C24:0	21.70±3.51	7.32±0.59	8.61±1.08
C26:1	0.76±0.21	0.10±0.02	0.12±0.02
C26:0	0.30±0.15	0.01±0.00	0.01±0.00