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. Author manuscript; available in PMC: 2016 Feb 23.
Published in final edited form as: Nat Commun. 2015 Aug 12;6:7556. doi: 10.1038/ncomms8556

Figure 7. Cryogel-free bolus vaccines containing irradiated B16-F10 cells, GM-CSF and CpG ODN confer no therapeutic efficacy.

Figure 7

A comparison of the survival (A) and tumor growth (B) of C57BL/6J mice bearing established melanoma tumors (inoculated with 5 × 105 B16-F10 cells and allowed to develop for 3 days, tumor area ≥ 10 mm2, 6 mice/group) and therapeutically treated with a cryogel-free bolus vaccine (Bolux Vax 1X: 4 × 105 irradiated B16-F10 cells + soluble 3 μg GM-CSF + soluble 100 μg CpG ODN) at day 3; or cryogel-free bolus vaccines (Bolux Vax 2X: 4 × 105 irradiated B16-F10 cells + soluble 3 μg GM-CSF + soluble 100 μg CpG ODN) at both days 3 and 10; and (Control, no immunization): naïve mice.