Table 1. Selected Data from Optimization Studya.
entry | catalyst | temp (°C) | cat. loading (% mol) | yieldb |
---|---|---|---|---|
1 | AuCl | 50 | 2.5 | 0 |
2 | AuCl3 | 50 | 2.5 | 0 |
3 | IPrAuOAc | 50 | 2.5 | 0 |
4 | IPrAuOTs | 50 | 2.5 | 34 |
5 | IPrAuTFA | 50 | 2.5 | 90 |
6 | NaTFA | 50 | 2.5 | 0 |
7 | None | 50 | 0 | 0 |
8 | IPrAuCl | 50 | 2.5 | 0 |
9 | AgTFA | 50 | 2.5 | 48 |
10 | IPrAuTFA | 50 | 1.0 | 85c |
11 | IPrAuTFA | 50 | 5.0 | 90 |
12 | IPrAuTFA | 50 | 10 | 92 |
13 | IPrAuTFA | 25 | 10 | 89d |
Reactions were carried out on a 0.10 mmol scale.
Yields were determined by the ERECTIC method using mesitylene as 1H NMR external standard.
23 h.
22 h.