Studies that met inclusion/exclusion criteria for systematic review about comorbid BD-OCD
| reference | study design | country | study population | diagnostic method; criteria | results | study qualitya |
| BD, bipolar disorder | DSM, Diagnostic and Statistical Manual of Mental Disorders | |||||
| OCD, obsessive-compulsive disorder | SCID, Structured Clinical Interview | |||||
| MDE, major depressive disorder | NS, Not specified | |||||
| aaChecklist for measuring study quality developed by Downs and Black[6] | ||||||
| Angst 2005[7] | prospective cohort | Switzerland | 591 subjects recruited at age 19 or 20 and assessed over 20 years: OCD (n=30), BD (n=93) OCD-BD (n=44) | Broad
definition
for BD and
OCD;
DSM-IV |
No statistically significant differences in family history for OCD, depression, or mania in OCD patients with or without BD comorbidity | 26/31 |
| Berutti 2014[8] | cross sectional | Brazil | BD (n=488) age>18 | SCID;
DSM-IV |
BD patients with a family history of mood disorders presented with significantly higher lifetime prevalence of OCD | 24/31 |
| Koyuncu 2010[9] | case control | Turkey | BD (n=214) mean age=34.8 (10.3) BD-OCD (n=35) mean age=36.2 (15.9) | SCID;
DSM-IV |
Higher prevalence of OCD in firstdegree relatives of BD-OCD patients versus that in relatives of non-BD-OCD patients (45.7% vs. 5.7%); no statistically significant differences in family history for BD | 20/31 |
| Mahasuar 2011[10] | case control | India | OCD (n=91) mean age=29.4 (8.3), BD-OCD (n=34) mean age=28.4 (7.1) | SCID;
DSM-IV |
Statistically non-significant trends of higher prevalence of family history for mood disorders in BD-OCD patients and lower prevalence of family history for OCD versus those in non-BD-OCD patients | 19/31 |
| Perugi 1998[11] | case control | Italy | OCD (n=135) mean age=38.4 (13.3) | NS;
DSM-III-R |
Positive correlation between episodic OCD and family history for mood disorders compared with patients with continuous OCD (54.1% vs. 34.7%) | 21/31 |
| Perugi 2002[12] | case control | Italy | OCD-MDE (n=68) mean age=34.2 (12.5) BD-OCD (n=38) mean age=35.9 (12.2) | SCID;
DSM-IV |
Statistically non-significant trends of higher prevalence of family history for mood disorders and lower prevalence of family history for OCD in BD-OCD patients versus those in non-BD-OCD patients | 20/31 |
| Shashidhara 2015[13] | cross sectional | India | BD-I (n=396, age>18) | SCID; DSM-IV | Higher prevalence of family history for mood disorders in BD-OCD patients compared to family history in OCD patients (33.3% vs. 6.7%) | 23/31 |
| Zutshi 2007[14] | case control | India | OCD (n=106) mean age=26.5 (7.4) BD-OCD (n=28) mean age=27.9 (6.7) | SCID;
DSM-IV |
Compared to non-BD-OCD patients, BD-OCD patients have higher prevalence of family history for mood disorder (36% vs. 6%) and lower prevalence of family history for OCD (0.0% vs. 21%) | 20/31 |