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. 2016 Feb 19;11(Spec Iss):21–30. doi: 10.2147/COPD.S85978

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© 2016 Pavord et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Receiver operating characteristic curve illustrating that blood eosinophils are a marker of sputum eosinophil-associated exacerbations.

Note: Adapted with permission of the American Thoracic Society. Copyright © 2016 American Thoracic Society. Bafadhel M, McKenna S, Terry S, et al. 2011. Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med. Volume 184(6), Pages 662–671. The American Journal of Respiratory and Critical Care Medicine is an official journal of the American Thoracic Society.¹¹

Abbreviations: IL, interleukin; CCL, chemokine ligand; TNF, tumor necrosis factor; VCAM, vascular cell adhesion molecule.