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. Author manuscript; available in PMC: 2016 Feb 23.
Published in final edited form as: Sci Signal. 2015 Jun 23;8(382):ra61. doi: 10.1126/scisignal.aab0715

Fig. 3. Induction of excitatory synaptic scaling by inhibition of DNA methylation is activity-dependent.

Fig. 3

(A) Sample mEPSC traces from cortical pyramidal neurons after 24 hours of exposure to control (CTL), RG108 + APV (magenta), RG018 + APV + NBQX (purple), or RG108 + TTX (green). (B and C) Cumulative probability distributions and mean mEPSC amplitudes (B) and mean mEPSC frequencies (C) from cortical pyramidal neurons treated with RG108 and APV; RG108, APV, and NBQX; or RG108 and TTX. Bar graphs are means ± SEM. Data are cumulative of cells pooled from at least three experiments for each condition (CTL, n = 17 cells; RG108 + APV, n = 9 cells; RG108 + APV + NBQX, n = 6 cells; and RG108 + TTX, n = 12 cells). (B) *P < 0.001 compared to CTL, Kruskal-Wallis (K-W) test followed by Dunn’s test. (C) *P < 0.05 compared to CTL, analysis of variance (ANOVA) followed by Dunnett’s test.