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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Mol Genet Metab. 2015 Oct 29;116(4):281–288. doi: 10.1016/j.ymgme.2015.10.011

Fig. 4.

Fig. 4

The impact of aryl phosphoramidate Ppan derivatives on the intracellular CoA content in Pank1−/− mouse embryo fibroblasts. The four control conditions were vehicle-treated wild-type fibroblasts (WT) (n=4), Pank1−/− (KO) fibroblasts (n=14) (dark bars); Pank1−/− fibroblasts treated with either 200 µM Pan (n=2) or 200 µM Ppan (n=2). Pank1−/− fibroblasts were treated with 200 µM Compounds 1–8 (n=2 per group). CoA levels (pmol/106 cells) were determined as described under Experimental Procedures. Significance was determined with respect to the KO values using the Student’s t-test: * p<0.05; ** p<0.005; *** p<0.0005).