Figure 4.

Effects of oral resveratrol (RES) supplementation on NF-κB expression in aortic arch in high cholesterol diet-fed apo E-/- mice as determined by (A), (B) and (C) immunohistochemical staining and (D) immunohistochemistry immunoreactivity scoring. All photomicrographs were subjected to magnification for histological analysis (X 100). Arrows indicate positive NF-κB immunoreactivity. Results are expressed as mean±SEM of 6 animals in each group. *, P<0.05, determined using the Mann-Whitney nonparametric test, high-dose RES-treated animals vs. controls group. Control: high cholesterol diet (#58R5) without RES treatment; Low-dose RES: high cholesterol diet (#58R5) + low-dose RES supplementation; High-dose RES: high cholesterol diet (#58R5) + high-dose RES supplementation