Table 3.
Combined association of CETP polymorphisms and BMI or birth weight with dyslipidemia
| TAQ1B | A373P | |||||
| CC | CT+TT | CC | CG+GG | |||
| BMI | ||||||
| Crude | OR (95%CI) | Pinteraction | OR (95%CI) | Pinteraction | ||
| Underweight | 1 | 0.13 (0.06, 0.27) | <0.001 | 1 | 3.27 (1.29, 8.29) | 0.02 |
| Normal | 1.25 (0.64, 2.43) | 0.18 (0.09,0.33) | 1.26 (0.82, 1.94) | 5.65 (2.90, 11.02) | ||
| Overweight+ obese | 1.98 (0.82, 4.78) | 0.48 (0.22, 1.02) | 2.95 (1.71, 5.07) | 4.23 (0.95, 4.60) | ||
| Adjusted* | ||||||
| Underweight | 1 | 0.10 (0.04, 0.24) | <0.001 | 1 | 3.43 (1.20, 9.74) | 0.01 |
| Normal | 1.14 (0.55, 2.38) | 0.16 (0.08, 0.33) | 1.28 (0.79, 2.09) | 5.69 (2.69, 12.02) | ||
| Overweight+ obese | 1.67 (0.63, 4.44) | 0.49 (0.21, 1.12) | 3.17 (1.72, 5.83) | 4.36 (0.83, 4.75) | ||
| Birth weight | ||||||
| Crude | OR (95%CI) | Pinteraction | OR (95%CI) | Pinteraction | ||
| BW<2500 g | 1 | 0.09 (0.03, 0.25) | <0.001 | 1 | 2.68 (0.78, 9.12) | 0.003 |
| BW=2500-4000 g | 0.34 (0.14, 0.86) | 0.06 (0.03, 0.16) | 0.55 (0.34, 0.89) | 2.58 (1.27, 5.24) | ||
| BW>4000 g | 1.21 (0.27, 5.39) | 0.04 (0.01, 0.13) | 0.66 (0.32, 1.37) | 1.70 (0.46, 6.28) | ||
| Adjusted¶ | ||||||
| BW<2500 g | 1 | 0.22 (0.07, 0.69) | <0.001 | 1 | 4.01 (0.97, 10.48) | 0.02 |
| BW=2500-4000 g | 0.26 (0.09, 0.74) | 0.11 (0.04, 0.27) | 0.51 (0.30, 0.86) | 2.16 (0.98, 4.74) | ||
| BW>4000 g | 0.95 (0.18, 4.79) | 0.06 (0.02, 0.26) | 0.61 (0.27, 1.38) | 1.55 (0.38, 6.30) | ||
CETP= cholesterol ester transfer protein, BMI= body mass index, BW= birth weight
*
Adjusted for age, sex, physical activity, waist circumference, birth weight, socioeconomic status, healthy and unhealthy food intake
¶
Adjusted for age, sex, physical activity, waist circumference, BMI, socioeconomic status, healthy and unhealthy food intake