Table 5.
Correlation of relapse and NRM with patient, disease, and transplant characteristics
| Relapse % (95% CI) | NRM % (95% CI) | ||||||
|---|---|---|---|---|---|---|---|
| 1 year | 2 year | p-value | day 100 | 1 year | 5 years | p-value | |
| Overall | 11.8 (6.4-18.9) | 15.7 (9.4-23.4) | - | 7.8 (3.7-14.1) | 22.5 (15.0-31.1) | 33.4 (24.2- | - |
| Age | 0.389 | 0.230 | |||||
| ≤ 50 | 11.5 (2.8-27.1) | 23.1 (9.1-40.8) | 0.00 (NA) | 15.4 (4.7-31.9) | 26.9(11.6- | ||
| 50-65 | 12.7 (5.9-22.2) | 14.3 (7.0-24.1) | 7.9 (2.9-16.3) | 20.6 (11.6-31.4) | 31.8 (20.7- | ||
| > 65 | 7.7 (0.4-30.6) | 7.7 (0.4-30.6) | 23.1 (5.1-48.5) | 46.2 (17.7-70.8) | 53.8 (22.8- | ||
| Etiology | 0.843 | 0.222 | |||||
| 10.3 (5.1-17.8) | 14.9 (8.4-23.3) | 6.9 (2.8-13.5) | 21.8 (13.8-31.1) | 32.3 (22.7- | |||
| Therapy-related | 20.0 (4.4-43.5) | 20.0 (4.4-43.5) | 13.3 (2.0-35.4) | 26.7 (7.7-50.6) | 40.0 (15.4-63.9) | ||
| Cytogenetic risk at diagnosis | 0.011 | 0.338 | |||||
| Very good/good | 4.3 (0.8-13.0) | 4.3 (0.8-13.0) | 12.8 (5.1-24.0) | 23.4 (12.5-36.3) | 34.0 (20.9- | ||
| Intermediate | 5.3 (0.3-22.0) | 15.8 (3.7-35.6) | 0.00 (NA) | 5.3 (0.3-22.1) | 21.1 (6.2- | ||
| Poor/very poor | 25.0 (11.5-41.1) | 31.2 (16.0-47.8) | 6.3 (11-18.4) | 28.1 (13.8-44.4) | 37.5 (20.8- | ||
| Pre-transplant therapy | 0.031 | 0.071 | |||||
| Chemotherapy | 9.0 (3.6-17.3) | 10.5 (4.5-19.2) | 9.0 (3.6-17.3) | 28.4 (18.1-39.5) | 38.9 (27.2- | ||
| Hypomethylating agents | 18.8 (7.5-34.0) | 28.1 (13.8-44.4) | 6.3 (11-18.4) | 9.4 (2.3-22.5) | 21.9 (9.4-37.6) | ||
| Conditioning regimen | 0.352 | 0.841 | |||||
| Chemotherapy | 10.3 (5.1-17.8) | 13.8 (7.5-22.0) | 9.2 (4.3-16.4) | 21.8 (13.8-31.1) | 33.3 (23.7- | ||
| Total Body Irradiation | 20.0 (4.5-43.5) | 26.7 (7.6-50.8) | 0.00 (NA) | 26.7 (7.7-50.6) | 33.3(11.3-57.5) | ||
| Match Type | 0.607 | 0.807 | |||||
| Match-related | 10.8 (03.4-23.3) | 16.2 (6.4-29.9) | 5.4 (0.9-16.1) | 21.6 (10.0-36.1) | 32.6 (18.0- | ||
| Match-unrelated | 13.2 (4.7-26.0) | 13.2 (4.7-26.0) | 13.2 (4.7-26.0) | 23.7 (11.6-38.2) | 31.6 (17.5- | ||
| Mismatch | 11.1 (2.7-26.3) | 18.5 (6.5-35.3) | 3.7 (0.03-16.2) | 22.2 (8.8-39.4) | 37.0 (19.2- | ||
| HCT-CI | 0.845 | 0.382 | |||||
| 0 | 5.6 (0.3-23.1) | 11.1 (1.7-30.5) | 0.00 (NA) | 16.7 (3.9-37.2) | 22.2(6.6- | ||
| 1-2 | 11.5 (2.8-27.2) | 15.4 (4.6-31.9) | 7.7 (13-22.1) | 23.1 (9.1-40.7) | 30.8 (14.3- | ||
| ≥ 3 | 14.0 (6.5-24.4) | 17.5 (8.9-28.5) | 10.5 (4.2-20.1) | 22.8 (12.9-344) | 36.8 (24.4- | ||
| CD 34 selection | 0.797 | 0.664 | |||||
| Clinimacs | 8.3(2.1-20.3) | 13.9 (5.0-27.3) | 8.3(2.1-20.3) | 22.2(10.3-37.0) | 30.6(16.4- | ||
| Isolex | 13.6 (6.7-23.1) | 16.7 (8.8-26.7) | 7.6(2.8-15.6) | 22.7(13.5-33.5) | 34.8 (23.5- | ||