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. 2015 Dec 2;65(3):687–698. doi: 10.2337/db15-0713

Table 1.

Results of morphometric and cell proliferation analyses

Islet size Total β-cell area Total α-cell area Relative β-cell area Relative α-cell area β-Cell proliferation index
P2
 Control (n = 3) 8.2 ± 0.4 6.0 ± 0.2 2.0 ± 0.2 74.0 ± 2.0 25.0 ± 3.5 32.0 ± 0.2
 Prox1endOE (n = 5) 7.2 ± 0.7 4.9 ± 0.5 2.7 ± 0.4 69.0 ± 1.6 38.2 ± 2.5 14.1 ± 2.8
 P value 0.33 0.12 0.09 0.09 0.02 0
P7
 Control (n = 3) 9.6 ± 1.1 8.0 ± 0.8 1.7 ± 0.3 82.6 ± 2.2 18.6 ± 3.0 9.2 ± 0.6
 Prox1endOE (n = 6) 6.3 ± 0.7 4.8 ± 0.6 1.9 ± 0.1 73.5 ± 2.0 32.9 ± 3.4 3.4 ± 0.5
 P value 0.03 0.02 0.5 0.03 0.03 0.001

Islet size = synaptophysin+ area × 103 U area. Total (β/α) cell area = (insulin/glucagon)+ area × 103 U area. Relative (β/α) cell area = (insulin/glucagon)+ area/total islet area × 103 U area. β-Cell proliferation index = number of Ki67+ cells/insulin+ area. U are arbitrary units as determined by the AxioVision software. Numbers in bold indicate significant P values. Results are shown as mean ± SEM.