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. 2015 Dec 31;25(6):1059–1073. doi: 10.1093/hmg/ddv621

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© The Author 2015. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Schematic illustration of the processes regulated by Wnt4 during female reproductive tract development. Wnt4 is required during prenatal and postnatal development of female reproductive tract. The initial MD primordium occurs independently of Wnt4 function (E11.5, the MD primordium in red). After initiation of the process, differentiation of the MD tip cells, prenatal elongation of the MD and postnatal formation of the endometrial gland (eG) all depend on Wnt4 signalling. The daughter cells that are initially Wnt4+ contribute to MD and eG formation. Myo, myometrium; E, endometrium; eG, endometrial glands; L, lumen.