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XMetS is a positive allosteric modulator (PAM) of the INSR. Studies were performed in cultured CHO cells engineered to express the human INSR. (A) XMetS positively enhanced insulin binding to the INSR. (B) XMetS enhanced insulin-induced INSR autophosphorylation. (C) XMetS enhanced insulin-induced pAkt phosphorylation. (D) XMetS enhanced insulin-induced glucose uptake.
