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Pharmacokinetic/pharmacodynamic modeling of U-500R doses at steady-state: 500 U QD, 250 U BID, 165 U TID. QD doses were administered at 7 am, BID doses at 7 am and 6 pm, and TID doses at 7 am, 12 noon, and 6 pm. The hatched area represents the 90th prediction interval from the model; the thicker line represents the median.
