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. 2016 Feb 22;10(2):e0004451. doi: 10.1371/journal.pntd.0004451

Table 1. Gene ontology (GO) enrichment analysis for up- and down-regulated genes.

DE class Category GO term DE trans. (total) p-value FDR
Up-regulated Biological Process proteolysis 26 (840) 7.10E-09 1.90E-05
innate immune response 12 (212) 2.10E-07 3.10E-04
immune response 13 (272) 4.00E-07 4.80E-04
protein processing 11 (200) 1.10E-06 1.30E-03
protein maturation 11 (206) 1.50E-06 1.60E-03
defense response to other organism 11 (220) 2.50E-06 2.40E-03
zymogen activation 8 (110) 4.70E-06 4.20E-03
maternal specification of dorsal/ventral axis, oocyte, germ-line encoded 8 (115) 7.10E-06 6.00E-03
defense response 14 (410) 8.00E-06 6.00E-03
defense response to bacterium 9 (173) 1.60E-05 1.00E-02
serine family amino acid metabolic process 5 (39) 2.10E-05 1.30E-02
oocyte dorsal/ventral axis specification 8 (139) 2.40E-05 1.40E-02
Toll signaling pathway 8 (139) 2.60E-05 1.50E-02
response to bacterium 9 (186) 2.80E-05 1.50E-02
response to other organism 11 (294) 3.20E-05 1.60E-02
sterol transport 5 (44) 3.40E-05 1.70E-02
immune system process 13 (418) 3.70E-05 1.80E-02
oocyte axis specification 8 (152) 4.20E-05 1.90E-02
alpha-amino acid metabolic process 9 (196) 4.70E-05 2.10E-02
response to external stimulus 17 (701) 5.30E-05 2.30E-02
response to external biotic stimulus 11 (329) 8.70E-05 3.50E-02
response to biotic stimulus 11 (332) 9.50E-05 3.70E-02
dorsal/ventral axis specification 8 (171) 1.00E-04 3.70E-02
cholesterol efflux 4 (30) 1.10E-04 3.90E-02
Molecular Function peptidase activity, acting on L-amino acid peptides 30 (963) 1.50E-10 1.00E-06
peptidase activity 30 (991) 3.00E-10 1.40E-06
endopeptidase activity 25 (740) 1.30E-09 4.40E-06
serine-type endopeptidase activity 18 (419) 1.80E-08 4.00E-05
serine-type peptidase activity 18 (457) 6.70E-08 1.30E-04
serine hydrolase activity 18 (465) 8.70E-08 1.50E-04
hydrolase activity 44 (2541) 3.40E-07 4.60E-04
sterol transporter activity 4 (16) 8.50E-06 6.00E-03
cholesterol transporter activity 4 (16) 8.50E-06 6.00E-03
lipid transporter activity 6 (63) 9.80E-06 6.60E-03
glycine dehydrogenase (decarboxylating) activity 2 (2) 6.50E-05 2.60E-02
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor 2 (2) 6.50E-05 2.60E-02
substrate-specific transporter activity 17 (725) 9.80E-05 3.70E-02
metalloendopeptidase activity 6 (94) 1.40E-04 4.70E-02
Cellular Component extracellular region 41 (1220) 2.20E-15 2.90E-11
Down-regulated Molecular Function carboxypeptidase activity 6 (49) 2.80E-07 2.00E-03
metallopeptidase activity 10 (214) 4.20E-07 2.00E-03
exopeptidase activity 9 (164) 4.50E-07 2.00E-03
peptidyl-dipeptidase activity 3 (8) 1.40E-05 4.50E-02