Fig 2.
Concentration response curves showing the effects of the agonist APNEA in the absence and presence of 8SPT (10-5M) in (A) normotensive rats and (B) spontaneously hypertensive rats. Concentration response curves to APNEA were analysed using nonlinear regression, from which EC50 values and 95% confidence intervals were also derived. One-way or two-way ANOVA were performed on the data, followed by Tukey’s Multiple Comparison Test/Bonferroni for individual comparisons when significant effects were detected. *denotes statistical significant difference (p<0.05) to absence of antagonist group.