Skip to main content
. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Br J Haematol. 2015 Dec 18;172(5):794–806. doi: 10.1111/bjh.13862

Figure 5. Resveratrol improves the function of stored human platelets in an in vitro model of transfusion.

Figure 5

Human platelets were collected from healthy donors and processed according to standard blood banking procedures. Platelet concentrates were treated with vehicle (Veh) or 10 μM resveratrol (Resv.) prior to storage and stored for up to 5 days at room temperature with agitation. Thrombocytopenic whole blood (B) was generated from fresh whole blood (A). Stored control platelets (C) or stored resveratrol-treated platelets (D) (20 × 109/l) were mixed at a 1:4 ratio with autologous fresh thrombocytopenic whole blood. Thromboelastography was measured within 2 h of collection. The maximum amplitude (MA; mm; indicated by dotted line) was measured for each sample. One representative donor from day 5 post-storage (A–D) and quantification of 3 independent donors (E) are shown. The platelet counts following transfusion were measured (F). Mean +/− SEM. n=3 Statistical significance was determined by Two-Way RM ANOVA with Dunnett’s post-test. *p<0.05