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. Author manuscript; available in PMC: 2016 Dec 15.
Published in final edited form as: Bioorg Med Chem Lett. 2015 Dec 15;25(24):5661–5666. doi: 10.1016/j.bmcl.2015.11.019

Figure 1.

Figure 1

Protein-protein interaction of p53 peptide (orange α-helix with sticks) with MDM2 (grey surface) (PDB ID 1YCR). Key amino acids Leu22 (marine sticks), Phe19 (green sticks), Trp23 (blue sticks) and Leu26 (red sticks) are mounted onto the orange p53 α-helix. Leu26 is embedded into the hydrophobic receptor amino acids Ile99, Ile103, Leu54 and Val93. The Trp23 pocket is formed by Leu57, Phe86 and Ile99. The Phe19 pocket consists of Val93, Gln72, Val75, Tyr67, Met62, Il261 and Gly58. Val93 undergoes hydrophobic interactions with p53Leu22.