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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Atherosclerosis. 2016 Jan 8;246:148–156. doi: 10.1016/j.atherosclerosis.2016.01.008

Fig. 1.

Fig. 1

Identification of a tagSNP for CAV1 by linkage disequilibrium (LD) analysis and significant association of SNP rs3807989 with expression of CAV1 mRNA. (A) Overview of LD of the 36.4 kb genomic region spanning CAV1. The LD structure was derived from MAF of SNPs for the Chinese population from the HapMap database (http://www.hapmap.org, phase1, 2&3) using Haploview 4.2. CAV1 has only one LD and rs3807989 captures all genomic information of the LD. (B-D) eQTL analysis of rs3807989 for CAV1 in two independent groups of study subjects. Major allele G of rs3807989 was associated with decreased expression of CAV1 mRNA , whereas minor allele A was associated with increased expression of CAV1 mRNA under an additive model in two independent groups of samples (B, C) and in the combined group (D).