Table 2.
Allelic association of SNP rs3807989 with CAD and MI in Chinese Han populations and the combined population.
| Study population | Sample size | Major/Risk Allele | MAF (case/control) | Before adjustment | After adjustment | |||
|---|---|---|---|---|---|---|---|---|
| Case/Control | P obs | OR (95%CI) | P adj | OR (95%CI) | ||||
| CAD | Population I | 1,249/841 | G/A | 0.277/0.237 | 3.23E-03 | 1.24 (1.07-1.43) | 8.04E-03 | 1.27 (1.06-1.51) |
| Population II | 1,260/833 | G/A | 0.300/0.261 | 6.87E-03 | 1.21 (1.05-1.39) | 1.98E-03 | 1.29 (1.10-1.52) | |
| Population III | 790/1,212 | G/A | 0.344/0.302 | 5.89E-03 | 1.21 (1.06-1.38) | 5.67E-03 | 1.21 (1.06-1.39) | |
| Combined | 3,299/2,886 | G/A | 0.302/0.269 | 1.84E-04 | 1.16 (1.07-1.26) | 2.18E-05 | 1.19 (1.10-1.29) | |
| Subgroups | Male | 2,145/1,822 | G/A | 0.306/0.273 | 1.43E-03 | 1.17 (1.06-1.29) | 4.71E-04 | 1.19 (1.08-1.32) |
| Female | 1,154/1,064 | G/A | 0.295/0.268 | 0.052 | 1.14 (0.99-1.30) | 1.76E-02 | 1.19 (1.03-1.36) | |
| MI | Population I | 568/841 | G/A | 0.276/0.237 | 1.71E-02 | 1.23 (1.04-1.46) | 2.87E-02 | 1.27 (1.03-1.58) |
| Population II | 609/833 | G/A | 0.305/0.261 | 1.51E-02 | 1.23 (1.04-1.44) | 9.60E-03 | 1.30 (1.07-1.58) | |
| Population III | 304/1,212 | G/A | 0.370/0.302 | 4.35E-04 | 1.40 (1.16-1.68) | 4.62E-04 | 1.40 (1.16-1.69) | |
| Combined | 1,481/2,886 | G/A | 0.306/0.269 | 2.25E-04 | 1.20 (1.09-1.32) | 5.43E-05 | 1.23 (1.11-1.36) | |
| Subgroups | Male | 1,036/1,822 | G/A | 0.295/0.273 | 8.12E-03 | 1.17 (1.04-1.32) | 4.60E-03 | 1.19 (1.06-1.34) |
| Female | 445/1,064 | G/A | 0.313/0.268 | 8.04E-03 | 1.26 (1.06-1.50) | 3.25E-03 | 1.33 (1.10-1.62) | |
Pobs: P value for association before adjusting for covariates by 2×2 contingence tables using PLINK version 1.07; Padj: P value for association after adjusting for covariates of hypertension, DM, smoking, alcohol intake, gender and age by multiple logistic regression analysis using SPSS version17.0; OR: odds ratio; 95% CI: 95% confidential interval.