Table 1.
Baseline demographics and clinical features of the sample
| Measure |
Treatment
|
||
|---|---|---|---|
| Donepezil (N=11) Mean (SD) | Placebo (n=7) Mean (SD) | p value | |
| Demographics | |||
| Age in years | 66.5 (9.8) | 67.0 (9.00) | >0.9 |
| Education in years | 13.1 (3.8) | 11.7 (6.1) | >0.5 |
| Gender (% Female) | 45 | 86 | >0.1 |
| Clinical | |||
| MMSE (0-30) | 25.7 (2.0) | 25.9 (2.5) | >0.8 |
| 24-item HRSD | 8.5 (6.9) | 8.4 (4.1) | >0.1 |
| Neuropsychological | |||
| Verbal Memory | |||
| SRT-tot | 32.0 (12.2) | 41.8 (15.4) | >0.1 |
| Verbal Fluency | |||
| COWAT-CFL | 32.6 (12.5) | 36.7 (13.6) | >0.5 |
| Attention/Psychomotor | |||
| Trailmaking A | 73.4 (22.9) | 107.1(68.1) | >0.2 |
| Executive | |||
| Trailmaking B | 195.9 (91) | 137.8 (66) | >0.2 |
| WAIS-III digit symbol | 42.3 (17.5) | 35.5 (22.8) | >0.4 |
| Olfaction | |||
| UPSIT (0-40) | 28 (4.7) | 28 (6.9) | >0.8 |
Patients with depression and cognitive impairment (DEP-CI) were randomized to donepezil or placebo. MMSE: Mini Mental State Exam, HRSD-24: 24-item Hamilton Rating Scale for Depression, SRT- tot: Selective Reminding Test- total recall, COWAT-CFL: CFL-version of the Controlled Oral Word Association Test, WAIS: Wechsler Adult Intelligence Scale, UPSIT: University of Pennsylvania Smell Identification Test.