Table 3.
Events | Cohort | HR | (95% CI) | |
---|---|---|---|---|
Pre- to post-diagnosis weight changec | ||||
Loss of 5–10% | 129 | 595 | 1.16 | (0.95–1.41) |
Loss of ≥10% | 69 | 348 | 1.17 | (0.53–2.59) |
Stable | 599 | 3217 | 1.00 | (reference) |
Gain of 5–10% | 199 | 1021 | 1.08 | (0.85–1.36) |
Gain of ≥10% | 187 | 1001 | 1.06 | (0.82–1.38) |
BMI at 2 years post-diagnosis (kg/m2)c | ||||
<21.5 | 151 | 784 | 1.19 | (0.98–1.45) |
21.5–24.99 | 314 | 1877 | 1.00 | (reference) |
25–29.9 | 400 | 2093 | 1.05 | (0.81–1.37) |
30–34.99 | 211 | 970 | 1.12 | (0.78–1.63) |
≥35 | 133 | 535 | 1.37 | (0.93–2.01) |
Ptrend | 0.19 | |||
Post-diagnosis BMI using second available weight measurement (kg/m2)d | ||||
<21.5 | 144 | 716 | 1.42 | (1.15–1.74) |
21.5–24.99 | 244 | 1702 | 1.00 | (reference) |
25–29.9 | 320 | 1927 | 1.06 | (0.90–1.26) |
30–34.99 | 162 | 891 | 1.11 | (0.91–1.36) |
≥35 | 92 | 445 | 1.40 | (1.09–1.81) |
Ptrend | 0.013 | |||
Post-diagnosis recreational physical activity (MET-h/wk) | ||||
0–<4.9 | 503 | 2027 | 1.00 | (reference) |
4.9–<17.4 | 382 | 2076 | 0.81 | (0.71–0.93) |
≥17.4 | 324 | 2156 | 0.71 | (0.61–0.82) |
Ptrend | <0.0001 | |||
Post-diagnosis alcohol consumption (g/day)c | ||||
Non-drinker | 529 | 2491 | 1.00 | (reference) |
0.36–6 | 328 | 1864 | 0.94 | (0.81–1.08) |
<6–<12 | 121 | 676 | 1.00 | (0.64–1.57) |
≥12 | 185 | 1055 | 0.93 | (0.75–1.17) |
Ptrend | 0.29 | |||
Smoking status at first post-diagnosis survey | ||||
Never | 513 | 3045 | 1.00 | (reference) |
Former <20 pack-years | 268 | 1751 | 0.94 | (0.81–1.09) |
Former ≥20 pack-years | 266 | 996 | 1.46 | (1.25–1.70) |
Current | 144 | 408 | 2.20 | (1.82–2.66) |
Adjusted for age at diagnosis, TNM stage, PR status, chemotherapy, radiotherapy, surgery, hormonal therapy, race/ethnicity, menopausal status, comorbidity (diabetes, hypertension), studied lifestyle factors (as appropriate), and time between exposure measurement and 5-year post diagnosis date, stratified by study. Models for weight change also adjusted for pre-diagnosis BMI.
Table limited to 5-year survivors. In addition, specific models excluded the following: 82 missing pre-diagnosis BMI (for weight change models), 252 missing alcohol intake (for alcohol models), 65 missing pack-year information (smoking models).
The Q statistic was statistically significant for one exposure category for three models (weight loss ≥10%, P =0.036, post-diagnosis BMI 30–34.99 kg/m2, P =0.016, alcohol intake of 6–<12 g/day, P =0.0095); therefore, the results were from a random effects meta-analysis for these models.1
Using second post-diagnosis weight instead of first post-diagnosis weight, assessed at on average 4.6 years after diagnosis.
Model excludes women with second weight measured after recurrence (n=31). Excludes and additional 547 women missing second measurement of BMI.