. Author manuscript; available in PMC: 2016 Nov 12.

Published in final edited form as: J Med Chem. 2015 Oct 20;58(21):8542–8552. doi: 10.1021/acs.jmedchem.5b01035

Table 1.

Summary of Transport of [⁷⁶Br]5 and [¹²³I]5 by System A, System L, and Other Neutral Amino Acid Transporters^a

system	types of compounds transported	sodium dependency	mechanism of transport	known system inhibitors	[⁷⁶Br]5 system transport	[¹²³I]8 system transport
A	small, neutral amino acids (Ala, Gly, etc.), recognizes N-methylated derivatives	yes	co-transport with Na⁺, unidirectional	MeAlB	yes	yes
L	large, branched, neutral amino acids (Leu, Phe, Tyr, etc.)	no	exchange (LAT1, LAT2), facilitated diffusion (LAT3, LAT4)	BCH	yes	no
neutral amino acid transport (including ASC)	small, neutral amino acids (Ala, Ser, Cys, etc.)	yes	multiple mechanisms	Ala, Cys, Ser	yes	no

Amino acid transporter system transport is designated as yes or no based on the results of the in vitro cell uptake assays.