Figure 2. Effect of DRMs on sequence diversity.
(A) For the most common reverse transcriptase and protease mutations, 95% confidence intervals are drawn for the difference in diversity associated with a single derived mutation. For each DRM, the mean diversity among patients with a fixed ancestral state at the focal locus is compared to those patients with that fixed non-ambiguous DRM. All sequences have no additional DRMs. All DRMs occurring at least 5 times with these specifications are included. (B) The effect of multiple DRMs on diversity is shown as the average diversity level of sequences decreases conditional on number of fixed drug resistance mutations present. Means SE are plotted among all patients in the D-PCR dataset.
Figure 2—figure supplement 1. Diversity and the number of drug resistance mutations by treatment categories.
The relationship between diversity and the number of drug resistance mutations is plotted separated out by the major treatment categories included in our analysis: (A) NRTI(s) without any other drugs, (B) NRTIs with unboosted PI, (C) NRTIs and an NNRTI and (D) NRTIs and PI/r. Data plotted is just the abundant treatment dataset.
Figure 2—figure supplement 2. Effect of multiple DRMs on sequence diversity separated by subtype.
Average diversity level of sequences are plotted conditioned on number of fixed drug resistance mutations present separately by all the subtypes with more than 100 associated HIV populations. Means SE are plotted among all the D-PCR dataset.