Table 1.

Modified definitions for organ dysfunction

Organ dysfunction	Original definitions	Modified definitions
Respiratory	paO2/FiO2 < 300	Intubation
Renal	Creatinine increase >0.5 mg/dL or urine output <0.5 mL/kg/h for at least 2 h	Creatinine increase >0.5 mg/dLa
Coagulopathy	INR >1.5 or aPTT >60 s	n/a
Hematologic	Platelet count <100,000/uL	n/a
Liver	Total bilirubin >4 mg/dL	n/a

paO2 arterial partial pressure of oxygen, FiO2 fractional oxygen percentage, INR international normalized ratio, aPTT activated partial thromboplastin time

^aIf a patient did not have a prior visit and the initial creatinine >2.0 mg/dL, we assessed if there was a >50 % decrease in creatinine in the first 96 h of hospital care