Table 2.
Associations with involution progression using multivariate logistic regression
| Characteristic | LI progression (N = 507) (%) | LI stasis (N = 327) (%) | Multivariate | |
|---|---|---|---|---|
| Odds ratio (95 % CI) | Wald p value | |||
| Time from Index to later benign biopsy | <.001 | |||
| <2 | 44 (8.7) | 82 (25.1) | 1.00 (ref) | |
| 2–5 | 98 (19.3) | 97 (29.7) | 2.10 (1.21, 3.65) | |
| 5–10 | 130 (25.6) | 86 (26.3) | 3.58 (2.08, 6.14) | |
| 10+ | 235 (46.4) | 62 (19.0) | 9.18 (5.30, 15.89) | |
| Age at index bx | <.001 | |||
| <45 | 273 (53.8) | 189 (57.8) | 1.00 (ref) | |
| 45–55 | 192 (37.9) | 105 (32.1) | 2.24 (1.50, 3.35) | |
| 55+ | 42 (8.3) | 33 (10.1) | 1.89 (1.00, 3.58) | |
| Involution at index | <.001 | |||
| 0–25 % TDLU | 223 (44.0) | 77 (23.5) | 1.00 (ref) | |
| 26–50 % TDLU | 182 (35.9) | 104 (31.8) | 0.50 (0.33, 0.76) | |
| 51–75 % TDLU | 102 (20.1) | 146 (44.6) | 0.16 (0.10, 0.26) | |
| HRT ever/never | 0.482 | |||
| No | 172 (39.1) | 113 (41.5) | 1.00 (ref) | |
| Yes | 268 (60.9) | 159 (58.5) | 0.88 (0.62, 1.26) | |
AH atypical hyperplasia, BBD benign breast disease, NP nonproliferative disease, PDWA proliferative disease without atypia, TDLU terminal duct lobular units. All shown covariates were modeled simultaneously in a single multivariate model
a p value is from an overall type 3 wald test