Figure 3.

Partition coefficients of everolimus (blue), paclitaxel (red) and sirolimus (green) in atherosclerotic human aorta. Partition coefficient was greatest in the medial layer (left) where lipid content was lowest, whilst it was lowest in the intimal layer (right) where lipid content was most abundant. These data were obtained from a single sample dissected into three tunic layers, cut into 12 sections, and immersed in drug solution for 96 h (n = 3 for each layer and drug). Figure adapted from Tzafriri et al. 2010.63