Table 1. Clinical characteristics of the discovery and replication cohorts with mismatch-repair proficient colorectal cancer.
| Characteristic | Exome cohort (%) N = 55 | Dutch replication cohort (%) N = 82 | German replication cohort (%) N = 92 | |
|---|---|---|---|---|
| Average age of onset (SD) | 35 (4) | 40.4 (4.5) | 37.7 (5.6) | |
| Average age | ||||
| ≤25 yr | 2 (4) | 1 (1) | 1 (1) | |
| 25–30 yr | 8 (15) | 2 (2) | 12 (13) | |
| 31–35 yr | 17 (31) | 10 (12) | 16 (17) | |
| 36–40 yr | 26 (47) | 21 (26) | 27 (29) | |
| 40–45 yr | 2 (4) | 46 (56) | 35 (38) | |
| 45–50 yr | - | 2 (2) | 1 (1) | |
| Family history for cancer | ||||
| None | 27 (49) | 23 (28) | 4 (4) | |
| ≥one first degree relative | 10 (18) | 33 (40) | 37 (3) | |
| ≥one second degree relative | 10 (18) | 13 (16) | 20 (22) | |
| ≥one third degree relatives | 2 (4) | 1 (1) | 1 (1) | |
| Unknown | 6 (11) | 12 (15) | 30 (33) | |
| Tumor location | ||||
| Right colon | 8 (15) | 7 (9) | 15 (16) | |
| Transverse colon | 4 (7) | 8 (10) | 9 (10) | |
| Left colon | 13 (24) | 13 (16) | 25 (27) | |
| Rectum | 25 (46) | 32 (39) | 33 (36) | |
| Unknown | 6 (11) | 19 (23) | 10 (11) | |