Table 3. Comparison of neuropilin-1 (NRP-1) and neuropilin-2 (NRP-2) expression on alveolar macrophages in lung cancer adjacent to the cancer margin, lung inflammation and lung tissue remote to the cancer nest (physiologically normal lung).
Cases/Diseases | Number of NRP-1 positive cellsA) (mean ± SD) | Number of NRP-2 positive cellsA) (mean ± SD) |
---|---|---|
Adenocarcinoma (n = 15) | 38.3 ± 8.9‡, # | 37.8 ± 9.20‡, # |
Squamous cell carcinoma (n = 15) | 46.7 ± 9.2*, *** | 48.1 ± 10.7*, *** |
Inflamed lung (n = 20) | 25.1 ± 9.1*, **, ‡ | 24.5 ± 12.1*, **, ‡ |
Physiologically normal lung (n = 5) | 9.2 ± 3.8**, ***, # | 8.9 ± 3.9**, ***, # |
* p< 0.01 significant between squamous cell carcinoma and inflamed lung;
** p< 0.01 significant between inflamed lung and physiologically normal lung;
*** p< 0.01 significant between squamous cell carcinoma and physiologically normal lung;
‡ p< 0.05 significant between adenocarcinoma and inflamed lung and
# p< 0.01 significant between adenocarcinoma and physiologically normal lung by the Mann-Whitney U-test.
A), average number of positive cells/high-power view fields.