. 2016 Feb 22;11(2):e0147358. doi: 10.1371/journal.pone.0147358

Table 3. Comparison of neuropilin-1 (NRP-1) and neuropilin-2 (NRP-2) expression on alveolar macrophages in lung cancer adjacent to the cancer margin, lung inflammation and lung tissue remote to the cancer nest (physiologically normal lung).

Cases/Diseases	Number of NRP-1 positive cells^A) (mean ± SD)	Number of NRP-2 positive cells^A) (mean ± SD)
Adenocarcinoma (n = 15)	38.3 ± 8.9^‡^, ^#	37.8 ± 9.20^‡^, ^#
Squamous cell carcinoma (n = 15)	46.7 ± 9.2^^, ^**	48.1 ± 10.7^^, ^**
Inflamed lung (n = 20)	25.1 ± 9.1^^, ^*^, ^‡	24.5 ± 12.1^^, ^*^, ^‡
Physiologically normal lung (n = 5)	9.2 ± 3.8^^, ^*^, ^#	8.9 ± 3.9^^, ^*^, ^#

* p< 0.01 significant between squamous cell carcinoma and inflamed lung;

** p< 0.01 significant between inflamed lung and physiologically normal lung;

*** p< 0.01 significant between squamous cell carcinoma and physiologically normal lung;

^‡ p< 0.05 significant between adenocarcinoma and inflamed lung and

^# p< 0.01 significant between adenocarcinoma and physiologically normal lung by the Mann-Whitney U-test.

^A), average number of positive cells/high-power view fields.