Figure 3.

Relationship between hippocampus subfield structure and NREM SWA with learning. A, Hippocampal subfield segmentations. Left, Two-dimensional and three-dimensional representations of hippocampus CA1, CA3/DG, and subiculum subfields. Right, Scatterplot relating change in LDI-indexed learning ability to CA3/DG volume. Red data points indicate the impairment due to sleep deprivation (deprivation − rested). Blue data points indicate the magnitude of postrecovery restoration in learning (recovery − deprivation). Lines of best fit are plotted for each relationship. Unlike the impairment due to sleep loss, nonsignificant associations were observed between CA3/DG volume and LDI performance in the rested (r = −0.18, b = −36.65, p = 0.60), deprivation (r = 0.36, b = 43.26, p = 0.35), and recovery (r = 0.08, b = 13.78, p = 0.79) conditions, respectively. B, Associations with recovery SWA. Left, Two-dimensional and three-dimensional topographic plots of NREM SWA during the recovery nap. White circles represent the three electrodes (F7, T3, Cz) that were mutually predictive of both deprivation impairment, and recovery restoration, of learning. Right, Scatterplot relating change in pattern separation ability to NREM SWA (averaged across F7, T3, Cz). Red and blue data as in A above. **p < 0.005. *p < 0.05.