Table 3.
Comparisons of differential values (post-administration minus pre-administration) in T2DM patients with different SLC22A1 rs594709 and SLC47A1 rs2289669 genotypes before and after metformin treatment.
| Parameter | SLC22A1 rs594709 | p value | SLC47A1 rs2289669 | p value | ||
|---|---|---|---|---|---|---|
| AA/GA (n = 50) | GG (n = 3) | AA/GA (n = 37) | GG (n = 16) | |||
| FBG (mmol/L) | −2.02 ± 2.84 | −0.10 ± 0.62 | 0.112 | −2.15 ± 3.11 | −1.27 ± 1.72 | 0.668 |
| PBG (mmol/L) | −5.28 ± 6.03 | −1.73 ± 2.66 | 0.171 | −5.61 ± 6.17 | −3.84 ± 5.32 | 0.692 |
| FINS (mU/L) | 3.90 ± 5.40 | 11.35 ± 4.46 | 0.015a | 4.07 ± 6.06 | 5.19 ± 4.47 | 0.501 |
| PINS (mU/L) | −9.77 ± 25.58 | −20.58 ± 22.72 | 0.259 | −13.69 ± 29.73 | −3.53 ± 6.81 | 0.457 |
| HbA1c (%) | −2.83 ± 4.82 | −0.60 ± 0.53 | 0.227 | −2.89 ± 5.38 | −2.21 ± 2.64 | 1.000 |
| TG (mmol/L) | −0.84 ± 3.71 | −0.74 ± 1.28 | 0.434 | −0.72 ± 3.71 | −1.10 ± 3.44 | 0.163 |
| TChol (mmol/L) | −0.60 ± 1.46 | 0.05 ± 1.56 | 0.224 | −0.39 ± 1.40 | −0.96 ± 1.55 | 0.030b |
| LDL-C (mmol/L) | −0.14 ± 1.00 | −0.09 ± 0.78 | 0.451 | −0.08 ± 1.10 | −0.28 ± 0.63 | 0.049b |
| HDL-C (mmol/L) | −0.03 ± 0.18 | −0.05 ± 0.15 | 0.399 | −0.02 ± 0.19 | −0.08 ± 0.14 | 0.254 |
| HOMA-IR | 0.60 ± 2.87 | 3.06 ± 0.72 | 0.081 | 0.55 ± 3.27 | 1.31 ± 1.31 | 0.357 |
| HOMA-IS | −0.003 ± 0.03 | −0.08 ± 0.10 | 0.001a | −0.009 ± 0.05 | −0.009 ± 0.02 | 0.382 |
| HOMA-B | 0.90 ± 1.70 | 0.96 ± 0.70 | 0.493 | 0.86 ± 1.48 | 1.01 ± 2.06 | 0.295 |
| QUICKI | −0.03 ± 0.17 | −0.43 ± 0.46 | 0.002a | −0.05 ± 0.25 | −0.07 ± 0.10 | 0.446 |
BMI: body mass index; FBG: fasting blood glucose; PBG: postprandial blood glucose; FINS: fasting insulin; PINS: postprandial insulin; HbA1c: glycosylated haemoglobin; TG: triglycerides; TChol: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostasis model assessment of insulin resistance; HOMA-IS: homeostasis model assessment of insulin sensitivity; HOMA-B: homeostasis model assessment of β-cell function; QUICKI: quantitative insulin sensitivity check index.
a p < 0.05 for comparison of GG genotype with GA/AA genotype of SLC22A1 rs594709 polymorphism, adjusted for age, sex, and BMI, in recessive model.
b p < 0.05 for comparison of GG genotype with GA/AA genotype of SLC47A1 rs2289669 polymorphism, adjusted for age, sex, and BMI, in recessive model.