Table 4.
The differential values (DV) of clinical characteristics per SLC22A1 rs594709 and SLC47A1 rs2289669 genotypes.
| SLC47A1 rs2289669 | SLC22A1 rs594709 AA (n = 32) | p value | SLC22A1 rs594709 GA/GG (n = 21) | p value | ||
|---|---|---|---|---|---|---|
| AA (n = 6) | GA + GG (n = 26) | AA (n = 7) | GA + GG (n = 14) | |||
| FBG (mmol/L) | −3.94 ± 6.25 | −1.63 ± 1.95 | 0.015a | −1.56 ± 2.61 | −1.81 ± 2.37 | 0.641 |
| PBG (mmol/L) | −9.63 ± 5.83 | −4.56 ± 5.84 | 0.067 | −3.32 ± 6.46 | −5.32 ± 5.79 | 0.310 |
| FINS (mU/L) | 5.17 ± 6.89 | 4.71 ± 4.28 | 0.252 | 3.25 ± 8.35 | 4.17 ± 6.41 | 0.865 |
| PINS (mU/L) | −31.68 ± 56.56 | −4.61 ± 20.91 | 0.041a | −13.72 ± 25.71 | −14.93 ± 22.25 | 0.799 |
| HbA1c (%) | −3.25 ± 3.11 | −3.33 ± 6.30 | 0.487 | −1.84 ± 1.43 | −1.76 ± 2.13 | 0.778 |
| TG (mmol/L) | −4.15 ± 6.97 | −1.05 ± 2.70 | 0.061 | −0.77 ± 2.20 | 0.69 ± 4.05 | 0.466 |
| TChol (mmol/L) | −1.28 ± 1.56 | −0.65 ± 1.46 | 0.197 | −1.33 ± 1.15 | 0.32 ± 1.26 | 0.013b |
| LDL-C (mmol/L) | 0.38 ± 1.35 | −0.09 ± 0.76 | 0.148 | −0.66 ± 0.49 | −0.11 ± 1.38 | 0.228 |
| HDL-C (mmol/L) | 0.09 ± 0.25 | −0.04 ± 0.20 | 0.134 | −0.10 ± 0.15 | −0.03 ± 0.11 | 0.205 |
| HOMA-IR | −2.02 ± 7.50 | 1.22 ± 1.36 | 0.014a | 0.34 ± 2.33 | 1.10 ± 2.77 | 0.841 |
| HOMA-IS | −0.01 ± 0.02 | −0.01 ± 0.02 | 0.440 | −0.02 ± 0.08 | 0.003 ± 0.05 | 0.345 |
| HOMA-B | 1.11 ± 0.74 | 0.81 ± 1.57 | 0.441 | 1.62 ± 2.90 | 0.57 ± 0.86 | 0.149 |
| QUICKI | −0.07 ± 0.13 | −0.07 ± 0.12 | 0.447 | −0.10 ± 0.42 | 0.0003 ± 0.25 | 0.437 |
BMI: body mass index; FBG: fasting blood glucose; PBG: postprandial blood glucose; FINS: fasting insulin; PINS: postprandial insulin; HbA1c: glycosylated haemoglobin; TG: triglycerides; TChol: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostasis model assessment of insulin resistance; HOMA-IS: homeostasis model assessment of insulin sensitivity; HOMA-B: homeostasis model assessment of β-cell function; QUICKI: quantitative insulin sensitivity check index.
a p < 0.05 for comparison of AA genotype with GA/GG genotype of SLC47A1 rs2289669 polymorphism in SLC22A1 rs594709 AA genotyped T2DM patients, adjusted for age, sex, and BMI, in dominant model.
b p < 0.05 for comparison of AA genotype with GA/GG genotype of SLC47A1 rs2289669 polymorphism in SLC22A1 rs594709 GA or GG genotyped T2DM patients, adjusted for age, sex, and BMI, in dominant model.