Table 1.
Genotype frequencies of variants of the IL4, IL4R, IL13, IL13RA1, and IL13RA2 genes in TB cases stratified for the size and number of cavities in chest radiographsA.
| Gene variant | Cavity score | OR | 95% CI | p | ||||
|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | |||||
| IL4-589 rs2243250 | N | 79 | 632 | 509 | 186 | |||
| CC | 63.3% | 55.7% | 54.2% | 57.0% | 1 | |||
| CT | 32.9% | 37.7% | 38.9% | 37.1% | 0.96 | 0.6–1.5 | 0.85 | |
| TT | 3.8% | 6.6% | 6.9% | 5.9% | 0.89 | 0.6–1.3 | 0.58 | |
|
| ||||||||
| IL13-1112 rs1800925 | N | 81 | 649 | 517 | 189 | |||
| CC | 29.6% | 29.7% | 34.0% | 28.0% | 1 | |||
| CT | 51.9% | 50.4% | 49.9% | 53.5% | 1.00 | 0.8–1.3 | 0.97 | |
| TT | 18.5% | 19.9% | 16.1% | 18.5% | 0.86 | 0.6–1.1 | 0.31 | |
|
| ||||||||
| IL4R I50V rs1805010 | N | 82 | 649 | 518 | 191 | |||
| GG | 28.0% | 26.0% | 24.1% | 25.1% | 1 | |||
| AG | 56.1% | 51.5% | 51.5% | 45.0% | 0.99 | 0.8–1.3 | 0.92 | |
| AA | 15.9% | 22.5% | 24.3% | 29.8% | 1.32 | 1.0–1.7 | 0.05 | |
| GG/AG∗ | 84.2%∗ | 77.5%∗ | 75.7%∗ | 70.2%∗ | 1∗ | |||
| AA∗ | 15.9%∗ | 22.5%∗ | 24.3%∗ | 29.8%∗ | 1.33∗ | 1.1–1.7∗ | 0.016∗ | |
|
| ||||||||
| IL13RA1 rs2495636 | N | 27 | 226 | 140 | 51 | |||
| Female | ||||||||
| AA | 88.9% | 86.3% | 85.7% | 84.3% | 1 | |||
| AG | 11.1% | 13.7% | 14.3% | 11.8% | 1.17 | 0.7–2.0 | 0.55 | |
| GG | 0.0% | 0.0% | 0.0% | 3.9% | nc | |||
|
| ||||||||
| IL13RA2 rs5946040 | N | 27 | 227 | 140 | 51 | |||
| Female | ||||||||
| GG | 48.1% | 47.1% | 47.9% | 31.4% | 1 | |||
| GT | 44.4% | 40.1% | 43.6% | 52.9% | 1.26 | 0.9–1.9 | 0.24 | |
| TT | 7.4% | 12.8% | 8.6% | 15.7% | 0.90 | 0.5–1.7 | 0.74 | |
|
| ||||||||
| IL13RA1 rs2495636 | N | 57 | 424 | 380 | 137 | |||
| Male | ||||||||
| A | 91.2% | 93.4% | 94.2% | 90.5% | 1 | |||
| G | 8.8% | 6.6% | 5.8% | 9.5% | 1.13 | 0.7–1.8 | 0.62 | |
|
| ||||||||
| IL13RA2 rs5946040 | N | 57 | 420 | 375 | 138 | |||
| Male | ||||||||
| G | 59.6% | 71.0% | 69.1% | 71.7% | 1 | |||
| T | 40.4% | 29.1% | 30.9% | 28.3% | 0.93 | 0.7–1.2 | 0.59 | |
AOdds ratios (OR) and 95% confidence intervals (CI) were calculated by ordinal logistic regression. nc, not calculable. As the IL13RA1 and the IL13RA2 genes are located on the X-chromosome, association testing was performed separately for males and females. Genotype frequencies of IL4R I50V in TB cases stratified for the size and number of cavities assuming a recessive mode of inheritance are followed by asterisk.