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. 2016 Feb 10;2016:9379840. doi: 10.1155/2016/9379840

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Copyright © 2016 Zaira F. Kharaeva et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dynamics of the pro- and anti-inflammatory cytokines IL-1β (a), IL-6 (b), and IL-10 (c) in the plasma (pg/mL). The experimental group (Exp, n = 39) was treated with conventional periodontal treatment plus topical daily application of fermented papaya gel into gingival pockets; the control group (Ctr, n = 45) received conventional periodontal treatment for the same period of time. Healthy donors: n = 25. The content of cytokines in plasma was quantified by ELISA method using corresponding monoclonal antibodies. Values are represented as mean and standard deviation of the mean (SD). IL-1β: interleukin 1β; IL-6: interleukin 6; and IL-10: interleukin 10. ^# P < 0.05 versus analogous day of treatment in the control group. ^∗ P < 0.05 versus healthy donors.