. Author manuscript; available in PMC: 2016 Feb 24.

Published in final edited form as: Adv Ther. 2010 Jun 3;27(5):257–284. doi: 10.1007/s12325-010-0028-3

Table 3.

Examples of antiatherosclerotic effects in selected randomized controlled trials^* of angiotensin II receptor blockers.

Agent	Study	Key findings
Valsartan	MARVAL-2	Significant reduction in arterial stiffness with valsartan/HCTZ vs. amlodipine/HCTZ in hypertensive patients with albuminuria, which was independent of BP lowering⁴²
Candesartan	CENTRO	Similar effects vs. enalapril on inflammatory markers of atherosclerosis in hypertensive patients with T2D⁶¹
Candesartan	MITEC	Similar effects vs. amlodipine on carotid IMT in hypertensive patients with T2D¹⁰⁷
Irbesartan	SILVHIA	Greater effectiveness vs. atenolol in reducing common carotid IMT in hypertensive patients with LVH⁷⁷
Olmesartan	EUTOPIA	Greater effectiveness vs. placebo in significantly reducing vascular microinflammation in a hypertensive population with a high prevalence of atherosclerotic disease¹⁰¹

BP=blood pressure; HCTZ=hydrochlorothiazide; IMT=intima-media thickness; LVH=left ventricular hypertrophy; T2D=type 2 diabetes.

In which the overall study population included >100 patients.