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. 2016 Feb 24;6:21838. doi: 10.1038/srep21838

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Copyright © 2016, Macmillan Publishers Limited

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(A,E,I) Transverse slice images of the LFJ both normal and at 3 and 7 days after injection with MIA. (B,F,J) 3D color-coding maps of the LFJ during the corresponding stages. (C,G,K) The 3D morphology of the subchondral bone in the SAP during the corresponding stages after injection with MIA. (D,H,L) The histological and morphological changes in the LFJ during the degeneration process in the early stage. (M) The scheme depicting the image analysis process for the subchondral bone. (N) The morphological change in the joint gap width of the LFJ during different stages. (O–T) The cartilage volume (CV), BV/TV and Tb.Th of the SAP and IAP at different stages after injection with MIA. (A,C,E,G,I,K) Bar = 1 mm. (B,F,J) Bar = 500 μm. (D,H,L) Bar = 100 μm.