Table 3. Results of the reliability and subgroup analysis of findings from the 17 DTI studies (18 datasets) with TBSS included in the meta-analysis.

Analysis	Region of FA reduction: Genu of CC	Region of FA reduction: ALIC
Jackknife sensitivity analysis (discarded study)
Excluding Zuo et al. 2012 [20]	Yes	Yes
Excluding Lai et al. 2014 [21]	Yes	Yes
Excluding Zhu et al. 2011 [22]	Yes	Yes
Excluding Versace et al. 2010 [23]	Yes	Yes
Excluding Choi et al. 2014 [24]	Yes	Yes
Excluding Murphy et al. 2012 [31]	Yes	Yes
Excluding Guo et al. 2012 [32]	Yes	Yes
Excluding Han et al. 2014 [33]	Yes	Yes
Excluding Hayashi et al. 2014 [34]	Yes	Yes
Excluding Kieseppa et al. 2010 [35]	Yes	Yes
Excluding Lyden et al. 2014 [36]	Yes	Yes
Excluding Olvet et al. nMDD 2014 [37]	Yes	No
Excluding Olvet et al. sMDD 2014 [37]	Yes	Yes
Excluding Seok et al. 2013 [38]	Yes	Yes
Excluding Guo et al. 2012 [39]	Yes	No
Excluding Korgaonkar et al. 2011 [40]	Yes	Yes
Excluding Wang et al. 2014 [41]	Yes	Yes
Excluding Xiao et al. 2015 [42]	Yes	No
Descriptive analysis of quartiles
First quartile (25%)	Yes	No
Second quartile (median)	Yes	No
Third quartile (75%)	No	No
Subgroup analysis
Studies with first-episode, treatment-naive MDD (n = 7)	No	Yes
Studies with Medication free MDD (n = 14)	Yes	Yes

“Yes” indicates that the brain region with FA reduction remained significant in the jack-knife analysis, descriptive analysis of quartiles and subgroup analysis; “No” indicates that the brain region with FA reduction was no longer significant in those analyses.

Abbreviations: DTI, diffusion tensor imaging; TBSS, tract-based spatial statistics; FA, fractional anisotropy; CC, corpus callosum; ALIC, anterior limb of internal capsule; MDD, major depressive disorder; nMDD, depressed patients without a history of suicide attempts; sMDD, depressed patients with a history of suicide attempts.