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. 2016 Feb 24;6:21722. doi: 10.1038/srep21722

Figure 1. Evolution of the partial bat AIM2 and the PYHIN PYRIN domains.

Figure 1

(a) Nucleotide sequence alignment comparing the partial AIM2 identified in the Parnell’s mustached bat genome to the PYRIN domain of human AIM2. A frameshift mutation due to a four-base-pair deletion and several premature stop codons (asterisks) indicate the loss of the PYRIN domain function in the bat. Identical nucleotides are highlighted in dark blue and deleterious mutations are shown in red boxes. Human AIM2 protein sequence positions were labeled above the alignment. (b) Phylogenetic tree of PYRIN domains from PYHIN proteins across mammalian groups. The bat PYRIN sequence is highlighted in red. The tree was rooted with marsupial sequences. Dotted boxes indicate the three distinct clades containing marsupial PYRIN, AIM2 PYRIN and non-AIM2 PYRIN respectively. Bootstrap values below 50% are not shown and branch lengths are drawn to a scale of amino acid substitutions per site.