Skip to main content
. 2016 Feb 24;6:21765. doi: 10.1038/srep21765

Figure 7. Virulence is enhanced by the incorporation of cryptococcal glycan fractions onto the surface of Hc yeast in a murine infection model.

Figure 7

(a) Enhanced mortality occurred when mice were infected with Hc cells and subsequently injected with E-gly-Cn or C-gly-Cn in comparison with Hc infected animals. (b) Mice treated with C-gly-Cn or E-gly-Cn after infection with Hc displayed higher fungal burdens in comparison to animals infected with Hc alone. When present, digits over graph points reveal the number of deceased animals at a specific time point, with CFUs expressed as averages. Results are representative of two-independent experiments with 7 animals per group. (c) Hc binds C-gly-Cn or E-gly-Cn in vivo, displaying a punctuate surface labelling of Hc GFP recovered from lungs of mice administered with the distinct pool of Cn-gly by GXM-binding mAb 2D10 (red) and Uvitex2B. In comparison, Hc recovered from lungs of monospecies infected Hc mice are not labelled by the mAb. Scale bar = 5 μm.