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. 2016 Feb 24;6:21945. doi: 10.1038/srep21945

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Representative double-plotted actograms (the same mice shown in Fig. 2) of wheel-running activity of Per1/2/3 triple mutant mice given methamphetamine (MA; indicated by dotted lines to the left of the actograms) in their drinking water (0.005%) in constant darkness. Actograms are plotted with a 21-h period. All individual actograms are shown in Supplementary Fig. S10.