Figure 1. Procedures for selecting radiosensitizer candidates from TOM-derived metabolite mimetic NF-κB inhibitors.

(a) Molecular structures of danshensu, synephrine, and vanillin, the three TOM-derived human metabolite mimetics examined during the present study. MW, molecular weight. (b) The chemical reaction catalyzed by MAOB. Hydrogen peroxide is produced during the reaction. (c,d) MAOB mRNA and protein expression levels were higher in A549 and NCI-H1299 cells (human NSCLC cell lines) than in MRC-5 and HFL-1 cells (human normal lung cell lines). *p < 0.05 when normal lung cell lines were compared with NSCLC cell lines. (e,f) The MAOB expression increased dose-dependently at the mRNA and protein levels in A549 and NCI-H1299 cells. (g) A schematic of the process used for identifying candidate of radiosensitizers among TOM-derived metabolite mimetic inhibitors of NF-κB.