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. 2016 Feb 24;6:21986. doi: 10.1038/srep21986

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(a) Morphological modifications observed in a 3D culture system suggested that IR-induced EMT was inhibited by danshensu and selegiline. (b,c) MAOB inhibition by danshensu significantly decreased irradiated NSCLC cell mobility as determined by the transwell cell migration and wound healing assays. *p < 0.05 vs. non-irradiated cells; **p < 0.05 vs. irradiated cells. (d,e) The mRNA and protein levels of EMT markers (E-cadherin-an epithelial marker, Vimentin and Fibronectin-mesenchymal markers) were assessed by qRT-PCR and Western blotting. Danshensu was found to reduce IR-induced EMT. *p < 0.05 vs. non-irradiated cells; **p < 0.05 vs. irradiated cells.