Table 2. Ex vivo coagulation time of compounds 1–4 from SSMa.
Sample | Dose | aPTT (s) | PT (s) | PT (INR) |
---|---|---|---|---|
Control | Saline | 30.2 ± 0.6 | 12.8 ± 0.4 | 1.00 |
Comp 1 | 1.73 μg/mouse | 45.9 ± 0.8* | 18.2 ± 0.8* | 2.33* |
3.46 μg/mouse | 59.5 ± 1.0* | 24.2 ± 1.2* | 4.61* | |
Comp 2 | 1.21 μg/mouse | 40.4 ± 0.6* | 15.9 ± 0.5* | 1.68 |
2.41 μg/mouse | 48.8 ± 0.8* | 20.8 ± 0.6* | 3.21* | |
Comp 3 | 0.81 μg/mouse | 31.2 ± 0.5 | 12.6 ± 0.4 | 0.96 |
1.61 μg/mouse | 30.8 ± 0.8 | 13.0 ± 0.9 | 1.04 | |
Comp 4 | 0.87 μg/mouse | 42.1 ± 0.7* | 17.4 ± 0.6* | 2.09* |
1.75 μg/mouse | 55.3 ± 1.0* | 22.4 ± 0.8* | 3.83* |
aEach value represents the means ± SEM (n = 5).
*p < 0.05 as compared to control.