Table 2. Ex vivo coagulation time of compounds 1–4 from SSM^a.

Sample	Dose	aPTT (s)	PT (s)	PT (INR)
Control	Saline	30.2 ± 0.6	12.8 ± 0.4	1.00
Comp 1	1.73 μg/mouse	45.9 ± 0.8*	18.2 ± 0.8*	2.33*
	3.46 μg/mouse	59.5 ± 1.0*	24.2 ± 1.2*	4.61*
Comp 2	1.21 μg/mouse	40.4 ± 0.6*	15.9 ± 0.5*	1.68
	2.41 μg/mouse	48.8 ± 0.8*	20.8 ± 0.6*	3.21*
Comp 3	0.81 μg/mouse	31.2 ± 0.5	12.6 ± 0.4	0.96
	1.61 μg/mouse	30.8 ± 0.8	13.0 ± 0.9	1.04
Comp 4	0.87 μg/mouse	42.1 ± 0.7*	17.4 ± 0.6*	2.09*
	1.75 μg/mouse	55.3 ± 1.0*	22.4 ± 0.8*	3.83*

^aEach value represents the means ± SEM (n = 5).

^*p < 0.05 as compared to control.