Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Feb 24;6:22113. doi: 10.1038/srep22113

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(A) SS18-SSX expression promotes interaction between β−catenin and HDAC1 in nuclei. Graphical representation with statistical analysis of PLAs using antibodies against the indicated proteins in C3H10T1/2^pLIVc (pLIVc) and C3H10T1/2^SS18-SSX1-V5 (SS-V5) cells. Correspondent representative fluorescence microscopy images are reported in Fig. S7. (B) LEF-1 depletion promotes SS18-SSX-HDAC1 association. Graphical representation of PLA as in (A). (C) TSA treatment inhibits SS18-SSX association with HDAC1. Representative fluorescence microscopy images of PLA using anti-V5 and anti-HDAC1 antibodies in C3H10T1/2^SS18-SSX1-V5 cells stimulated with 250 nM TSA or DMSO for 16hrs. Scale bar: 5 μm. (D,E) Effect of TSA treatment on LEF-1 interactions with HDAC (D) and SS18-SSX (E); graphical representation of PLA as in (A).