(A) Ribbon diagram of the various domains in individual colors - cyan (Ubl), grey (RING0), green (RING1), violet (IBR), blue (Rep), and bronze (RING2). The residues Ser65 (red), Arg275 (blue), and Cys431 (yellow) are highlighted in stick representation. (B) Juxtaposition of the ribbon diagram over a surface presentation of Parkin (Trempe et al., 2013).