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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: J Invest Dermatol. 2016 Mar;136(3):550–556. doi: 10.1016/j.jid.2015.10.065

Figure 1.

Figure 1

Genetic complexity of the pro-mineralization/anti-mineralization network. Mutations in specific genes (also see Table 1) can result in deposition of hydroxyapatite crystals in tissues in heritable ectopic mineralization disorders: PXE, pseudoxanthoma elasticum; GACI, generalized arterial calcification of infancy; ACDC, arterial calcification due to CD73 deficiency. The solid blue circles represent currently unidentified molecules postulated to be transported under physiologic homeostasis by ABCC6 from the intracellular (IC) space to extracellular (EC) milieu. Note that release of ATP from the hepatocytes has been shown to depend on active ABCC6. (Modified from Li and Uitto, 2013, with permission).