Figure 4.

Adoptive Transfer of CD4⁺CD25⁺ cells into CVB3 infected ERαKO female recipients. C57B/6, ERαKO and ERβKO female mice were infected with 10² PFU CVB3 and killed 7 days later. CD4⁺CD25⁺ T-cells were isolated from the spleen and 0, 10⁴ or 10⁵ cells were injected i.v. into infected female ERαKO recipients on the same day as infection. Recipients were killed 7 days later and evaluated for myocarditis. Results represent mean ± SEM of 4-6 mice/group. *Significantly different than C57Bl/6 mice at p<0.05.