Table 2.
Demographic and other baseline characteristics of patients included in the cardiovascular meta-analysis—all randomized patients (ITT population)
| Variable | All comparators (N = 2125) |
All dulaglutide (N = 3885) |
Total (N = 6010) |
p valuea |
|---|---|---|---|---|
| Mean age (years) | 56.0 | 56.2 | 56.1 | 0.78 |
| Age group [n (%)] | – | – | – | 0.30 |
| <65 years | 1724 (81.1) | 3177 (81.8) | 4901 (81.6) | |
| ≥65 years | 401 (18.9) | 708 (18.2) | 1109 (18.5) | |
| Sex [n (%)] | – | – | – | 0.27 |
| Female | 1016 (47.8) | 1916 (49.3) | 2932 (48.8) | |
| Male | 1109 (52.2) | 1969 (50.7) | 3078 (51.2) | |
| Ethnicity [n (%)] | – | – | – | 0.23 |
| Hispanic or Latino | 660 (31.1) | 1209 (31.1) | 1869 (31.1) | |
| Not Hispanic or Latino | 1463 (68.9) | 2676 (68.9) | 4139 (68.9) | |
| Raceb [n (%)] | – | – | – | 0.27 |
| American Indian or Alaska Native | 135 (6.4) | 231 (6.0) | 366 (6.1) | – |
| Asian | 271 (12.8) | 509 (13.1) | 780 (13.0) | – |
| Black or African American | 113 (5.3) | 245 (6.3) | 358 (6.0) | – |
| White | 1446 (68.1) | 2656 (68.4) | 4102 (68.3) | – |
| Mean duration of diabetes (years) | 8.0 | 7.9 | 7.9 | 0.22 |
| Duration of diabetes | – | – | – | 0.01 |
| <5 years | 765 (36.0) | 1494 (38.5) | 2259 (37.6) | |
| ≥5 and <10 years | 659 (31.0) | 1088 (28.0) | 1747 (29.1) | |
| ≥10 years | 701 (33.0) | 1303 (33.5) | 2004 (33.3) | |
| Mean BMI (kg/m2) | 32.4 | 32.3 | 32.3 | 0.51 |
| Fasting plasma glucose | ||||
| Mean (mmol/L) | 9.07 | 9.01 | 9.04 | 0.69 |
| <5.6 mmol/L [n (%)] | 109 (5.2) | 200 (5.2) | 309 (5.2) | 0.79 |
| ≥5.6 mmol/L [n (%)] | 1994 (94.8) | 3630 (94.8) | 5624 (94.8) | |
| HbA1c | ||||
| Mean (%) | 8.1 | 8.1 | 8.1 | 0.87 |
| Mean (mmol/mol) | 65.0 | 65.0 | 65.0 | |
| <8 % (<63.9 mmol/mol) [n (%)] | 1113 (52.6) | 2039 (52.6) | 3152 (52.6) | 0.62 |
| ≥8 % (≥63.9 mmol/mol) [n (%)] | 1005 (47.5) | 1838 (47.4) | 2843 (47.4) | |
BMI body mass index, HbA1c glycosylated hemoglobin A1c
aCategorical variables were compared between treatments by Cochran–Mantel–Haenszel test. Continuous variables were compared between treatments by ANOVA model adjusting for strata: variable = treatment + stratum
bCategories omitted from the table: Native Hawaiian or Other Pacific Islander (0.1 % total), multiple (0.9 % total), and unknown (5.7 % total)