Table 2.
The top 6 gene networks associated with the TBI-I dataset
| Network ID | Molecules in network | Score | Focus molecules | Top diseases and functions |
|---|---|---|---|---|
| 1 | CADM1, CALB1, CBFB, CDCA7L, CMIP, Cytochrome bc1, cytochrome-c oxidase, DAB2, DEDD, FGF9, FLNA, FYN, GCLC, GCLM, GFAP, GFRA1, ITGA6, JDP2, MAOA, MED14, MGEA5, NFE2L1, NFE2L2, NPTX1, NRP1, PDHA1, PDLIM7, RET, Rnr, RPS24, RTN4, SLC18A2, Sos, STK17B, TAF4B | 46 | 31 | Cell Death and Survival, Drug Metabolism, Molecular Transport |
| 2 | AMOT, ANXA1, API5, ATF3, ATG12, BAG3, CCNA2, Cdc2, CDK1, CDK2, CDKN1B, ETV5, FGFR3, FN1, GJA1, Hedgehog, LATS1, MCL1, MCM2, MCM8, MLLT4, MMS22L, NAA15, Patched, PIK3C2A, PKP2, PSMA7, RAB35, RPRM, SPIN1, TAGLN2, THOC2, TJP2, UNC5B, XPO1 | 46 | 32 | Cell Death and Survival, Cell Cycle, Reproductive System Development and Function |
| 3 | AHCTF1, AKAP12, amylase, BCL11A, CA4, CACNA1G, CCND1, CLCN7, CREB1, CREBBP, CSF1, CSRNP1, CTNNB1, DES, Histone h3, IKK (complex), ITPR2, KLF6, KPNB1, MITF, MTMR1, NFIX, PRKD3, PTGR1, RAI14, RNA polymerase II, RRM2, SENP2, SMAD4, SMARCA4, SUDS3, TBL1XR1, TGM2, THRA, ZBTB18 | 43 | 31 | Cell Death and Survival, Organismal Survival, Gene Expression |
| 4 | ABCA1, ALB, ALDH1A2, BTG2, Ccl2, Ccl7, CD36, CEBPB, chemokine, CREM, CXCL3, DUSP5, EGR2, FGF2, FGL2, FOSL1, FSH, Hmgb2 (includes others), HMOX1, IL1, IL12 (family), IL6R, ITGB2, KLF4, MAPK9, NEK6, NEK7, PDE4B, Pld, PRKCI, PTGS2, SPP1, THBD, TLR4, WNT5A | 42 | 30 | Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking |
| 5 | ACSL5, AGTR2, AMFR, AVP, CAMK2N1, CAPRIN1, CHSY1, CUL5, DCK, ELAVL1, Endothelin, GMCL1, GNRH, Insulin, MAP4K4, MSI2, MTORC1, NEO1, OPA1, Proinsulin, PTGER3, Relaxin, RNF2, SLC2A3, SMAD7, STAG1, TACR1, TCEB3, TMEM123, TRAF6, WAPAL, WFS1, WTAP, ZMYM2, ZNF280B | 41 | 29 | Cell Death and Survival, Cardiovascular System Development and Function, Hereditary Disorder |
| 6 | 26 s Proteasome, ARL11, BCL2L1, CAMK1G, CAMK2D, CASP3, CAV1, CISD2, CLASP1, CLN5, DLG4, EN2, ENC1, Esr1-Esr1-estrogen-estrogen, FBXO9, G2E3, Hsp70, Hsp90, HSP90AB1, IDE, KIF1B, MDM2, PCDH15, PGR, PI4K2A, PRDM2, PSEN1, SGPL1, SNCA, SPTBN1, SRC (family), SRPK2, TMEM109, TRIM2, VPS41 | 40 | 30 | Cell Death and Survival, Cancer, Neurological Disease |
Bold= > Gene included in the dataset
Note: Some of the nodes in the original networks represent gene groups, complexes or families that, when expanded, contain more potential GOI