. 2016 Feb 24;9:104. doi: 10.1186/s13071-016-1377-9

Table 1.

The Range, Arithmetic (AM) and Geometric (GM) Mean live Dermacentor reticulatus counts, and efficacy relative to placebo at 8 hours after treatment and re-infestations for dogs treated with either a single oral dose of sarolaner or a single topical application of imidacloprid+permethrin on Day 0

Treatment		Day of treatment or re-infestation
Treatment		0	7	14	21	28	35
Placebo	Range	23 to 43	12 to 34	26 to 43	13 to 40	21 to 39	20 to 43
	AM	33.8	23.5	35.8	28.4	32.4	35.4
	GM^c	32.4^a	21.7^a	34.5^a	26.4^a	31.2^a	33.7^a
Sarolaner	Range	0 to 31	6 to 21	8 to 22	12 to 27	13 to 30	12 to 33
	AM	8.3	13.1	12.5	19.9	22.1	21.1
	AM Efficacy (%)	75.6	44.1	65.0	30.0	31.7	40.3
	GM^c	3.4^b	12.1^b	11.6^b	18.6^a	20.6^a	19.8^b
	GM Efficacy (%)	89.6	44.1	66.4	29.6	33.9	41.2
	P-value vs. placebo	<0.0001	0.0157	<0.0001	0.1349	0.0766	0.0239
Imidacloprid+permethrin	Range	6 to 45	0 to 33	2 to 18	0 to 18	5 to 20	7 to 42
	AM	31.9	9.9	8.9	6.9	14.3	19.5
	AM Efficacy (%)	5.6	58.0	75.2	75.8	56.0	44.9
	GM^c	27.6^a	4.2^c	7.2^b	4.7^b	12.8^b	16.8^b
	GM Efficacy (%)	14.6	80.6	79.0	82.0	58.9	50.2
	P-value vs. placebo	0.6216	<0.0001	<0.0001	<0.0001	0.0074	0.0331
	P-value vs. sarolaner	<0.0001	0.0077	0.2152	0.0005	0.1917	0.6461

^c Geometric means within columns with the same superscript are not significantly different (P >0.05)